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Hydrophile Interaktionschromatographie (HILIC)


Liste von aktuellen Links zu wissenschaftlichen Publikationen von Merck SeQuant® Anwendern weltweit aus den unterschiedlichsten Anwendungsgebieten, um verschiedene schwierige chromatographische Fragestellungen zu lösen.


Wissenschaftliche Publikationen (Auswahl)




  • Molecular phylogeny and toxin profiles of Alexandrium tamarense (Lebour) Balech (Dinophyceae) from the west coast of Greenland
    C. Baggesen, Ø. Moestrup, N. Daugbjerg, B. Krock, A.D. Cembella, S. Madsen
    Harmful Algae 19 (2012) 108-116

  • Determination of glycine in biofluid by hydrophilic interaction chromatography coupled with tandem mass spectrometry and its application to the quantification of glycine released by embryonal carcinoma stem cells
    Y.B Tang, L. Teng, F. Sun, X.L. Wang, L. Peng, Y.Y. Cui, J.J. Hu, X. Luan, L. Zhu, H.Z. Chen
    J. Chromatogr. B 905 (2012) 61- 66

  • Effects of infusion conditions and decaffeination on free amino acid profiles of green and black tea
    T. Kocadağlı, K.S. Özdemir, V. Gökmen
    Food Research International xxx (2012)

  • A hydrophilic interaction liquid chromatography electrospray tandem mass spectrometry method for the simultaneous determination of g-hydroxybutyrate and its precursors in forensic whole blood
    L.K. Sørensen, J.B. Hasselstrøm
    Forensic Science International 222 (2012) 352-359

  • Non-targeted analysis of tea by hydrophilic interaction liquid chromatography and high resolution mass spectrometry
    K. Fraser, S.J. Harrison, G.A. Lane, D.E. Otter, Y. Hemar, S.Y. Quek, S. Rasmussen
    Food Chemistry 134 (2012) 1616-1623

  • Depletion of melamine and cyanuric acid in serum from catfish Ictalurus punctatus and rainbow trout Onchorhynchus mykiss
    C.B. Stine, C.B. Nochetto, E.R. Evans, C.M. Gieseker, T. D. Mayer, N.R. Hasbrouck, R. Reimschuessel
    Food and Chemical Toxicology 50 (2012) 3426-3432

  • Modern approach for determination of lactulose, mannitol and sucrose in human urine using HPLC-MS/MS for the studies of intestinal and upper digestive tract permeability
    P. Kubica, A. Kot-Wasik, A. Wasik, J. Namiesnik, P. Landowski
    J. Chromatogr. B 907 (2012) 34- 40

  • PSP toxin release from the cyanobacterium Raphidiopsis brookii D9(Nostocales) can be induced by sodium and potassium ions
    K. Soto-Liebe, M.A. Méndez, L. Fuenzalida, B. Krock, A. Cembella, M. Vásquez
    Toxicon 60 (2012) 1324-1334

  • Experimental design applied to the optimization of microwave-assisted DNA hydrolysis
    G. Marrubini, P. Fattorini, C. Previderéc, S. Goi, S.S. Cigliero, P. Grignani, M. Serra, R. Biesuz, G. Massolini
    J. Chromatogr. A 1249 (2012) 8- 16

  • Repeated exposure to codeine alters morphineglucuronidation by affecting UGT gene expression in the rat
    L. Antonilli, L. DeCarolis, V. Brusadin, A. R. Togna, M. Dovizio, G. I. Togna, P. Patrignani, P. Nencini
    European Journal of Pharmacology 693(2012)7-14

  • Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2
    T. Pfennig, B. Herrmann, T. Bauer, E. Schömig, D. Gründemann
    Biochimica et Biophysica Acta In press (2012)

  • A mass spectrometric method for quantifying C3 and C6 phosphorylation of starch
    M. Carpenter, N. Joyce, R. Butler, R. Genet, G. Timmerman-Vaughan
    Analytical Biochemistry 431 (2012) 115-119

  • Study of the retention behavior in zwitterionic hydrophilic interaction chromatography of isomeric hydroxy- and aminobenzoic acids
    G. Greco, S. Grosse, T. Letzel,

    J. Chromatogr. A, 12235 (2012) 60-67

  • Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts
    S. Kumar, F.M. Hahn, E. Baidoo, T.S. Kahlon, D.F. Wood, C.M. McMahan, K. Cornish, J.D. Keasling, H. Daniell, M.C. Whalen
    Metabolic Engineering. 14,(2012), 19-28

  • A liquid chromatography-tandem mass spectrometry method for the detection of economically motivated adulteration in protein-containing foods
    S. MacMahon, T.H. Begley, G.W. Diachenko, S.A. Stromgren
    J. Chromatogr. A 1220, (2012), 101-107

  • Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity
    C. Rakers, A.A. Zoerner, S. Engeli, S. Batkai, J. Jordan, D. Tsikas
    Analytical Biochemistry In Press, Corrected Proof

  • Simultaneous Analysis of Heparan Sulfate, Chondroitin/Dermatan Sulfates, and Hyaluronan Disaccharides by Glycoblotting-Assisted Sample Preparation Followed by Single-Step Zwitter-Ionic-Hydrophilic Interaction Chromatography
    Y. Takegawa, K.Araki, N. Fujitani, J. Furukawa, H. Sugiyama, H. Sakai, Y. Shinohara
    Anal. Chem.
    83, (2011), 9443-9449

  • Hydrophilic Interaction Liquid Chromatography: ESI-MS/MS of Plasmalogen Phospholipids from Pectinatus Bacterium T. Rezanka, L. Siristova, D. Matoulkova, K. Sigler
    Lipids 46, (2011), 765-780

  • Rapid and simultaneous determination of hexapeptides (Ac-EEMQRR-amide and H2N-EEMQRR-amide) in anti-wrinkle cosmetics by hydrophilic interaction liquid chromatography-solid phase extraction preparation and hydrophilic interaction liquid chromatography with tandem mass spectrometry
    W. Zhou, P.G. Wang, A.J. Krynitsky, J.I. Rader
    Journal of Chromatography A 1218, (2011), 7956-7963 
  • Isolation of activity and partial characterization of large non-proteinaceous lytic allelochemicals produced by the marine dinoflagellate Alexandrium tamarense
    H. Ma, B. Krock, U. Tillmann, A.Muck, N. Wielsch, A. Svatoš, A. Cembella
    Harmful Algae 11, (2011), 65-72 
  • Comparison of two aerosol-based detectors for the analysis of gabapentin in pharmaceutical formulations by hydrophilic interaction chromatography
    S. Jia, J.H. Park, J. Lee, S.W. Kwon
    Talanta 85, (2011), 2301-2306 
  • Development and validation of a hydrophilic interaction chromatography-tandem mass spectrometry method with on-line polar extraction for the analysis of urinary nucleosides. Potential application in clinical diagnosis
    E. Rodríguez-Gonzalo, D. García-Gómez, R. Carabias-Martínez
    Journal of Chromatography A 1218, (2011) 9055-9063 
  • Skeletal stem cell physiology on functionally distinct titania nanotopographies
    L.E. McNamaraa, T. Sjöström, K.E.V. Burgess, J.J.W. Kim, E. Liu, S. Gordonov, P.V. Moghe, R.M. D Meek, R.O.C. Oreffo, B. Su, M.J. Dalby
    Biomaterials 32, (2011), 7403-7410 
  • HPLC-UV method development for fentanyl determination in rat plasma and its application to elucidate pharmacokinetic behavior after i.p. administration to rats
    A.A. Almousa, R. Ikeda, M. Wada, N. Kuroda, R.K. Hanajiri, K. Nakashima
    Journal of Chromatography B 879, (2011), 2941-2944 
  • A 2H nuclear magnetic resonance study of the state of water in neat silica and zwitterionic stationary phases and its influence on the chromatographic retention characteristics in hydrophilic interaction high-performance liquid chromatography
    E. Wikberg, T. Sparrman, C. Viklund, T. Jonsson, K.Irgum
    Journal of Chromatography A 1218, (2011), 6630-6638
  • Characterisation and stability studies of a hydrophilic decapeptide in different adjuvant drug delivery systems: A comparative study of PLGA nanoparticles versus chitosan-dextran sulphate microparticles versus DOTAP-liposomes
    A. Wieber, T. Selzer, J. Kreuter

    International Journal of Pharmaceutics In Press, Corrected Proof :Pharmaceutical Nanotechnology
  • Zwitterionic-type hydrophilic interaction nano-liquid chromatography of complex and high mannose glycans coupled with electrospray ionisation high resolution time of flight mass spectrometry
    L. Mauko, M. Pelzing, S. Dolman, A. Nordborg, N.A. Lacher, P.R. Haddad, E.F. Hilder
    Journal of Chromatography A 1218, (2011), 6419-6425
  • Probing the interaction mode in hydrophilic interaction chromatography
    N.P. Dinh, T. Jonsson, K. Irgum
    Journal of Chromatography A 1218, (2011), 5880-5891
  • Chromatographic characterization of hydrophilic interaction liquid chromatography stationary phases: Hydrophilicity, charge effects, structural selectivity, and separation efficiency
    Y. Kawachi, T. Ikegami, H. Takuboa, Y. Ikegami, M. Miyamoto, N. Tanaka
    Journal of Chromatography A 1218, (2011), 5903-5919

  • Investigations on the chromatographic behaviour of zwitterionic stationary phases used in hydrophilic interaction chromatography
    R.I. Chirita, C. West, S. Zubrzyckia, A.L. Finaru, C. Elfakir
    Journal of Chromatography A 1218,(2011), 5939-5963

  • Application of hydrophilic interaction chromatography for the analysis of polar contaminants in food and environmental samples
    A.L.N. van Nuijs, I. Tarcomnicu, A. Covaci
    Journal of Chromatography A, 1218, (2011), 5964-5974

  • Hydrophilic interaction chromatography of nucleoside triphosphates with temperature as a separation parameter
    E. Johnsen, S.R. Wilson, I. Odsbu, A. Krapp, H. Malerod, K. Skarstad, E. Lundanes
    Journal of Chromatography A 1218,(2011), 5981-5986

  • Free amino acids in atmospheric particulate matter of Venice, Italy
    E. Barbaro, R. Zangrando, I. Moret, C.Barbante, P. Cescon, A. Gambaro
    Atmospheric Environment 45,(2011), 5050-5057 

  • Mode of action of membrane-disruptive lytic compounds from the marine dinoflagellate Alexandrium tamarense
    H. Ma, B. Krock, U. Tillmann, U. Bickmeyer, M. Graeve, A. Cembella
    Toxicon 58, (2011), 247-258

  • Screening method for the analysis of antiviral drugs in poultry tissues using zwitterionic hydrophilic interaction liquid chromatography/tandem mass spectrometry
    D. Chan, J. Tarbin, M. Sharman, M. Carson, M. Smith, S. Smith
    Analytica Chimica Acta 700, (2011), 194-200

  • Quantification of reduced and oxidized thiols in mouse serum by column-switching hydrophilic interaction chromatography coupled with mass spectrometry
    Y. Iwasaki, Y. Nakano, K. Mochizuki, T. Ogawa, M. Oda, R. Ito, K. Saito, H. Nakazawa
    Journal of Pharmaceutical and Biomedical Analysis 56, (2011), 103-113

  • Development of a molecularly imprinted polymer for selective extraction followed by liquid chromatographic determination of sitagliptin in rat plasma and urine
    R.N. Rao, P.K. Maurya, S. Khalid
    Talanta 85,(2011), 950-957

  • Analysis of oligonucleotides by hydrophilic interaction liquid chromatography coupled to negative ion electrospray ionization mass spectrometry
    L. Gong, J.S.O. McCullagh
    Journal of Chromatography A 1218,(2011), 5480-5486

  • No Observable Adverse Effects Level (NOAEL) for pigs fed melamine and cyanuric acid
    C.B. Stine, R. Reimschuessel, C.M. Gieseker, E.R. Evans, T.D. Mayer, N.R. Hasbrouck, E. Tall, J. Boehmer, G. Gamboa da Costa, J.L. Ward
    Regulatory Toxicology and Pharmacology 60, (2011), 363-372

  • Evaluation of different column types for the hydrophilic interaction chromatographic separation of iron-citrate and copper-histidine species from plants
    J. Köster, R. Shi, N. von Wirén, G. Weber
    Journal of Chromatography A 1218, (2011), 4934-4943

  • Microwave-assisted extraction and determination of cyanuric acid residue in infant formula samples by liquid chromatography-tandem mass spectrometry
    C. Han, C. Liu, Y. Zhou, B. Xia, Z. Zhu, X.Lei, Y. Shen
    Food Chemistry 127, (2011), 875-879

  • Study of retention behaviour and mass spectrometry compatibility in zwitterionic hydrophilic interaction chromatography for the separation of modified nucleosides and nucleobases

    E. Rodríguez-Gonzalo, D. García-Gómez, R. Carabias-Martínez

    Journal of Chromatography A 1218,(2011), 3994-4001

  • Determination of catecholamines in urine using hydrophilic interaction chromatography with electrochemical detection

    A. Kumar, J.P. Hart, D.V. McCalley 

    Journal of Chromatography A. 1218 (2011) 3854-3861

  • Screening and confirmatory methods for the determination of melamine in cow s milk and milk-based powdered infant formula: Validation and proficiency-tests of ELISA, HPLC-UV, GC-MS and LC-MS/MS
    P. Lutter, M.C. Savoy-Perroud, E. Campos-Gimenez, L. Meyer, T. Goldmann, M.C. Bertholet, P. Mottier, A. Desmarchelier, F. Monard, C. Perrin, F. Robert, T. Delatour
    Food Control 22, (2011) 903-913

  • Hydrophilic interaction liquid chromatography in food analysis
    J. Bernal, A.M. Ares, J. Pól, S.K. Wiedmer
    Journal of Chromatography A, 1218 (2011) 7438-7452

  • Surface modification of TiO2 for selective photodegradation of toxic compounds
    Y. Tominaga, T. Kubo, K. Hosoya
    Catalysis Communications, 12, (2011), 785-789

  • Sulfation of the 3,4-methylenedioxymethamphetamine (MDMA) metabolites 3,4-dihydroxymethamphetamine (DHMA) and 4-hydroxy-3-methoxymethamphetamine (HMMA) and their capability to inhibit human sulfotransferases
    A.E. Schwaninger, M.R. Meyer, J. Zapp, H.H. Maurer
    Toxicology Letters,202,(2011), 120-128

  • Development and validation of a highly sensitive LC-MS/MS method for organic cation transporter (OCT) substrate tetraethylammonium (TEA) in rabbits
    J. Nirmal, T. Velpandian, S. Baskar Singh, N.R. Biswas, V. Thavaraj, R. Azad, S. Ghose
    Journal of Chromatography B, 879, (2011), 585-590

  • Diurnal variations in depression-like behavior of Wistar and spontaneously hypertensive rats in the kainate model of temporal lobe epilepsy
    J. Tchekalarova, D. Pechlivanova, T. Atanasova, P. Markova, V. Lozanov, A. Stoynev

    Epilepsy & Behavior, 20, (2011), 277-285

  • Water ingestion during water recreation
    S. Dorevitch, S. Panthi, Y. Huang, H. Li, A.M. Michalek, P. Pratap, M. Wroblewski, L. Liu, P.A. Scheff, A. Li
    Water Research, 45, (2011), 2020-2028

  • Development and validation of a high-throughput double solid phase extraction-liquid chromatography-tandem mass spectrometry method for the determination of tetrodotoxin in human urine and plasma
    B.M.W Fong, S. Tam, S.H Tsui, K.S.Y Leung
    Talanta 83, (2011) 1030-1036

  • Hydrophilic Interaction Chromatography (HILIC) in the Analysis of Relevant Quality and Safety Biochemical Compounds in Meat, Poultry and Processed Meats
    L. Mora, A.S. Hernandez-Cazares, M.C. Aristoy, F Toldra, M. Reig

    Food Anal. Meth. 4 (2011) 121-129

  • Metabolomic profiling of biomarkers of liver X receptor-induced toxicity in mouse liver tissue
    L. MacIntyre, L.A. Zheng LA, P. Scullion, P. Keating, D.G. Watson DG

    Metabolomics 7 (2011) 54-70

  • A Novel Multidimensional Protein Identification Technology Approach Combining, Protein Size Exclusion Prefractionation, Peptide Zwitterion-Ion Hydrophilic Interaction Chromatography, and Nano-Ultraperformance RP Chromatography/nESI-MS2 for the in-Depth Analysis of the Serum Proteome and Phosphoproteome: Application to Clinical Sera Derived from Humans with Benign Prostate Hyperplasia
    S.D. Garbis, T.I. Roumeliotis, S.I. Tyritzis, K.M. Zorpas, K. Pavlakis, C.A. Constantinides

    Anal. Chem. 83 (2011) 708-718

  • Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites-The cardioprotectant dexrazoxane as a model case
    P. Kovarikova, J. Stariat, J. Klimes, K. Hruskova, K. Vavrova,

    J. Chromatogr. A 1218 (2011) 416-426  



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