PamGene
Aktueller Newsticker PamGene |
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PamGene entwickelt Anwendungen basierend auf einer patentierten Chip
Technologie Plattform um zellulare Kinase Aktivitäten als auch
Nuklear Rezeptor Aktivitäten zu messen und zu quantifizieren.
Sie können diese Technik nutzen,als Forscher...
wenn Sie :
Die PamGene Technologie kann:
Sie können diese Technik nutzen,als Mediziner... wenn Sie:
Die PamGene Technologie kann:
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PamChip
PamStation 12
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| Applikationsbeispiele | |||
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Die Broschüren mit den aktuellen Applikationen zu den Themenfeldern "General technology", "Kinasen" und "Nuclear Rezeptoren" können kostenlos hier herunter geladen werden. |
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 Download Applikationen |
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Aktuelle neue Applikationsnotes!
This study examined whether tumor kinase activity might also
correlate with systemic dissemination of rectal cancer. The
PamChip arrays helped to discriminate patients with respect to
the risk of disseminating tumor cells into the bone-marrow
environment
Currently, there is no uniform treatment of myeloproliferative
neoplasms, a group of diseases in the bone marrow. The data of
the study suggest that directly inhibiting STAT5 as well as
simultaneously inhibiting both STAT5 and Jak2, may be effective
strategies for the treatment of these diseases.
In the PamChip kinase assay tyrosine-kinase activity was
measured in blood platelets under various conditions. The
outcome of these experiments helped to formulate the hypothesis
that the Ephrin-receptor family is involved in platelet
function. This finding could assist in identifying processes
involved in cardio-vascular diseases.
In this study a search for factors identifying the patient
population responding to anti-angiogenic therapy was started.
Kinase activity profiling identified potential signaling
pathways that could lead to candidate markers for selection of
patients for anti-angiogenic therapy, and to identify targets to
combat treatment related resistance.
This study aimed at identifying the mechanisms of response or
resistance to ionizing radiation treatment. The PamChip assay
identified rapid changes in kinase activity but also identified
novel targets such as TrkA. TrkA inhibition resulted in
radioprotection that correlated with enhanced repair of
radiation-induced damage.
Generelle TechnologiePamGene Partnering Access to unique research capabilities in a partnership approach Functional testing of PamStation®12 microarray instrument performance BioNavigator, software to interpret PamChip® measurements Protein
tyrosine kinase assay robustness on PamChip® microarrays and The use of kinetic profiles in the statistical analysis of PamChip® data. PamIndex: biomarker discovery for Pamchip® assays
KinasenDevelopment
of Selective Bisubstrate-Based Inhibitors against Protein Kinome
Profiling in Pediatric Brain Tumors; Episodic Src activation in uveal melanoma revealed by kinase activity profiling Prediction
of survival in early stage non-small cell lung cancer (NSCLC) Protein-Tyrosine Kinase Activity Profiling in Knock Down Zebrafish Embryos Endogenous Phosphotyrosine Signaling in Zebrafish Embryos Application of kinase activity profiles to predict upcoming TKI resistance in CML-patients Understanding downstream signaling of the kinase RET WT and mutant. Substrate profiling of protein tyrosine kinases by multiplex kinase activity profiling Nuklear RezeptorenMARCoNI: analysis of Nuclear Receptor function in clinical samples |
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Die Gesamtinformationen zu den PamGene Produkten stehen im aktuellen Katalog zur Verfügung. Ihr persönliches Exemplar können Sie über unser Kontaktformular anfordern. Die aktuellen Bestellinformationen zum Download finden Sie hier: |
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